Passive acquired mucosal immunity to group A streptococci by secretory immunoglobulin A.
نویسندگان
چکیده
منابع مشابه
BriefDefinitive Report PASSIVE ACQUIRED MUCOSAL IMMUNITY TO GROUP A STREPTOCOCCI BY SECRETORY IMMUNOGLOBULIN A BY
M protein is a major surface component of group A streptococci, and more than 80 distinct serological types exist . Antigenic variability resides in the NH2-terminal distal portion ofthe fibrillarM protein molecule, whereas the COOH-terminal half is highly conserved among different M serotypes (1, 2) . With few exceptions, only serum IgGdirected to the antigenically variable portion ofM protein...
متن کاملPassive acquired mucosal immunity to group A streptococci by secretory immunoglobulin A
We present a model in which animals are passively immunized at a mucosal site, allowing one to evaluate immunological protection at the mucosal level only. Affinity-purified, anti-M protein sIgA administered intranasally protected mice against systemic infection after intranasal challenge with group A streptococci. In contrast, anti-M protein serum Ig administered intranasally was not protectiv...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1988
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.167.6.1945